Mathematical Analysis of HIV-1 Dynamics in Vivo
SIAM Review
Lie-Algebraic Stability Criteria for Switched Systems
SIAM Journal on Control and Optimization
Stability of Planar Switched Systems: The Linear Single Input Case
SIAM Journal on Control and Optimization
Maximum principle for optimal control problems with intermediate constraints
Computational Mathematics and Modeling
Stability analysis of switched systems using variational principles: An introduction
Automatica (Journal of IFAC)
| Hi-index | 22.14 |
This work is motivated by the drug therapy scheduling problem in HIV infection. Using simplified switched linear system models of HIV mutation and treatment with certain class of symmetry and finite horizon cost functions, we demonstrate that the optimal state and costate trajectories lie on a sliding surface where infinitely fast switching may occur. Results suggest that in the absence of other practical constraints, switching rapidly between therapies is relevant. Simulations show the potential benefits of a proactive switching strategy to minimize viral load and delay the emergence of resistant mutant viruses.