A faster algorithm for finding the minimum cut in a directed graph
SODA selected papers from the third annual ACM-SIAM symposium on Discrete algorithms
Theoretical Improvements in Algorithmic Efficiency for Network Flow Problems
Journal of the ACM (JACM)
Computers and Intractability; A Guide to the Theory of NP-Completeness
Computers and Intractability; A Guide to the Theory of NP-Completeness
Computing the Minimal Tiling Path from a Physical Map by Integer Linear Programming
WABI '08 Proceedings of the 8th international workshop on Algorithms in Bioinformatics
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The problem of computing the minimum tiling path (MTP) from a set of clones arranged in a physical map is a cornerstone of hierarchical (clone-by-clone) genome sequencing projects. We formulate this problem in a graph theoretical framework, and then solve by a combination of minimum hitting set and minimum spanning tree algorithms. The tool implementing this strategy, called FMTP, shows improved performance compared to the widely used software FPC. When we execute FMTP and FPC on the same physical map, the MTP produced by FMTP covers a higher portion of the genome, and uses a smaller number of clones. For instance, on the rice genome the MTP produced by our tool would reduce by about 11 percent the cost of a clone-by-clone sequencing project. Source code, benchmark data sets, and documentation of FMTP are freely available at http://code.google.com/p/fingerprint-based-minimal-tiling-path/ under MIT license.