Estimation of in vivo myocardial fibre strain using an architectural atlas of the human heart

  • Authors:

  • Christopher Casta;Vicky Y. Wang;Yue-Min Zhu;Brett R. Cowan;Pierre Croisille;Alistair A. Young;Martyn P. Nash;Patrick Clarysse

  • Affiliations:

  • CREATIS, CNRS UMR5220, INSERM U1044, INSA-Lyon, Univ. de Lyon, France;Auckland Bioengineering Institute, University of Auckland, New Zealand;CREATIS, CNRS UMR5220, INSERM U1044, INSA-Lyon, Univ. de Lyon, France;Centre for Advanced MRI, University of Auckland, New Zealand;CREATIS, CNRS UMR5220, INSERM U1044, INSA-Lyon, Univ. de Lyon, France;Auckland Bioengineering Institute, University of Auckland, New Zealand,Centre for Advanced MRI, University of Auckland, New Zealand;Auckland Bioengineering Institute, University of Auckland, New Zealand,Department of Engineering Science, University of Auckland, New Zealand;CREATIS, CNRS UMR5220, INSERM U1044, INSA-Lyon, Univ. de Lyon, France

  • Venue:
  • FIMH'13 Proceedings of the 7th international conference on Functional Imaging and Modeling of the Heart
  • Year:
  • 2013

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Abstract

We propose a methodology to estimate 3D+time maps of left ventricular (LV) fibre strain from human structural and dynamic MRI data. A biomechanical finite element model integrates fibre direction throughout the LV extracted from ex vivo human diffusion tensor MRI (DT-MRI) acquisition and motion tracked from tagged MRI (TMRI). This combination enables the estimation of fibre strain and its spatio-temporal variation throughout the cardiac cycle. The sensitivity of fibre strain estimation on the underlying fibre orientation is evaluated using a database of 7 DT-MRI and 1 TMRI datasets acquired on normal subjects. Our analysis indicates that the structure of the LV is designed for maximum homogeneity of fibre strain during ejection.