Intraventricular dyssynchrony assessment using regional contraction from LV motion models

  • Authors:

  • Avan Suinesiaputra;Brett R. Cowan;David A. Bluemke;Pau Medrano-Gracia;Daniel C. Lee;Jõao A. C. Lima;Alistair A. Young

  • Affiliations:

  • Anatomy with Radiology, University of Auckland, New Zealand;Anatomy with Radiology, University of Auckland, New Zealand;National Institute of Health Clinical Center;Anatomy with Radiology, University of Auckland, New Zealand;Feinberg Cardiovascular Research Institute, Northwestern University;Cardiovascular Imaging, The John Hopkins Hospital;Anatomy with Radiology, University of Auckland, New Zealand

  • Venue:
  • FIMH'13 Proceedings of the 7th international conference on Functional Imaging and Modeling of the Heart
  • Year:
  • 2013

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Abstract

A spatiotemporal 3D left ventricular (LV) motion model was developed to extract regional function for intra left ventricular dyssynchrony (intra-LVD). A finite element model was divided into the standard 17 segments. Temporal interpolation was performed by using periodic control theoretic smoothing splines. Intra-LVD was assessed in terms of systolic dyssynchrony index (SDI) by measuring the dispersion of time to reach peak regional ejection fraction (TPREF). We compared two patient groups: 300 asymptomatic (A: 139M/161F, mean age: 61±9.7 yrs) and 105 patients with myocardial infarction (P: 81M/24F, mean age: 63±10.2 yrs). Consistent regional variation in TPREF was observed in the A group, with the basal septal segments having later TPREF. Omitting these segments significantly reduced the SDI values in both groups (PP