Biclustering of Expression Data
Proceedings of the Eighth International Conference on Intelligent Systems for Molecular Biology
Block clustering with Bernoulli mixture models: Comparison of different approaches
Computational Statistics & Data Analysis
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In many applications, it is of interest to simultaneously cluster row and column variables in a data set, identifying local subgroups within a data matrix that share some common characteristic. When a small set of variables is believed to be associated with a set of responses, block clustering or biclustering is a more appropriate technique to use compared to one-dimensional clustering. A flexible framework for Bayesian model-based block clustering, that can determine multiple block clusters in a data matrix through a novel and efficient evolutionary Monte Carlo-based methodology, is proposed. The performance of this methodology is illustrated through a number of simulation studies and an application to data from genome-wide association studies.