Computational Steering Software Systems and Strategies
IEEE Computational Science & Engineering
Models for Computational Steering
ICCDS '96 Proceedings of the 3rd International Conference on Configurable Distributed Systems
SUNDIALS: Suite of nonlinear and differential/algebraic equation solvers
ACM Transactions on Mathematical Software (TOMS) - Special issue on the Advanced CompuTational Software (ACTS) Collection
COPASI---a COmplex PAthway SImulator
Bioinformatics
Hybrid method for the chemical master equation
Journal of Computational Physics
Petri nets for systems and synthetic biology
SFM'08 Proceedings of the Formal methods for the design of computer, communication, and software systems 8th international conference on Formal methods for computational systems biology
Discrete, Continuous, and Hybrid Petri Nets
Discrete, Continuous, and Hybrid Petri Nets
From petri nets to differential equations – an integrative approach for biochemical network analysis
ICATPN'06 Proceedings of the 27th international conference on Applications and Theory of Petri Nets and Other Models of Concurrency
Snoopy --- a unifying petri net tool
PETRI NETS'12 Proceedings of the 33rd international conference on Application and Theory of Petri Nets
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Computational steering is an interactive remote control of a long running application. The user can adopt it, e.g., to adjust simulation parameters on the fly. Simulation of large-scale biochemical networks is often computationally expensive, particularly stochastic and hybrid simulation. Such extremely time-consuming computations necessitate an interactive mechanism to permit users to try different paths and ask “what-if-questions” while the simulation is in progress. Furthermore, with the progress of computational modelling and the simulation of biochemical networks, there is a need to manage multi-scale models, which may contain species or reactions at different scales. In this context, Petri nets are of special importance, since they provide an intuitive visual representation of reaction networks. In this paper, we introduce a framework and its implementation for combining Petri nets and computational steering for the representation and interactive simulation of biochemical networks. The main merits of the developed framework are: intuitive representation of biochemical networks by means of Petri nets, distributed collaborative and interactive simulation, and tight coupling of simulation and visualisation.