National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD;National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD;National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD;National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD