ARIADNE: pattern-directed inference and hierarchical abstraction in protein structure recognition

Authors:
Richard H. Lathrop;Teresa A. Webster;Temple F. Smith
Affiliations:
Massachusetts Institute of Technology, Cambridge;Harvard Medical School, Boston, MA;Harvard Medical School, Boston, MA
Venue:
Communications of the ACM
Year:
1987

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Abstract

The macro-molecular structural conformations of proteins exhibit higher order regularities whose recognition is complicated by many factors. ARIADNE searches for similarities between structural descriptors and hypothesized protein structure at levels more abstract than the primary sequence.