Gene-finding via tandem mass spectrometry
RECOMB '01 Proceedings of the fifth annual international conference on Computational biology
Algorithms for identifying protein cross-links via tandem mass spectrometry
RECOMB '01 Proceedings of the fifth annual international conference on Computational biology
On de novo interpretation of tandem mass spectra for peptide identification
RECOMB '03 Proceedings of the seventh annual international conference on Research in computational molecular biology
WABI '02 Proceedings of the Second International Workshop on Algorithms in Bioinformatics
BioDM'06 Proceedings of the 2006 international conference on Data Mining for Biomedical Applications
An automata approach to match gapped sequence tags against protein database
CIAA'04 Proceedings of the 9th international conference on Implementation and Application of Automata
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Database search in tandem mass spectrometry is a powerful tool for protein identification. High-throughput spectral acquisition raises the problem of dealing with genetic variation and peptide modifications within a population of related proteins. A method that cross-correlates and clusters related spectra in large collections of uncharacterized spectra (i.e from normal and diseased individuals) would be extremely valuable in functional proteomics. This problem is far from being simple since very similar peptides may have very different spectra. We introduce a new notion of spectral similarity that allows one to identify related spectra even if the corresponding peptides have multiple modifications/mutations. Based on this notion we developed a new algorithm for mutation-tolerant database search as well as a method for cross-correlating related uncharacterized spectra. The paper describes this new approach and its applications in functional proteomics.