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Despite the size and importance of the health care industry, simulation is less prevalent in health care than in other fields such as manufacturing, logistics, and military applications. Yet simulation clearly has the potential to play a role in health care decision-making at many levels. The purpose of this panel is to discuss some of the issues that practioners must be aware of in order to tap the potential of simulation in the health care arena. The panelists have extensive experience in health care and the use of simulation in that environment. They have provided statements outlining several key issues for achieving success in current and future health care simulation projects. These will serve as the starting point for discussion at the conference.