Multiscale Segmentation of Three-Dimensional MR Brain Images

  • Authors:
  • W. J. Niessen;K. L. Vincken;J. Weickert;B. M. Ter Haar Romeny;M. A. Viergever

  • Affiliations:
  • Image Sciences Institute, University Hospital Utrecht, HP E01. 334, P.O. Box 85500, 3508 CX, The Netherlands. wiro@isi.uu.nl;Image Sciences Institute, University Hospital Utrecht, HP E01. 334, P.O. Box 85500, 3508 CX, The Netherlands;Image Sciences Institute, University Hospital Utrecht, HP E01. 334, P.O. Box 85500, 3508 CX, The Netherlands;Image Sciences Institute, University Hospital Utrecht, HP E01. 334, P.O. Box 85500, 3508 CX, The Netherlands;Image Sciences Institute, University Hospital Utrecht, HP E01. 334, P.O. Box 85500, 3508 CX, The Netherlands

  • Venue:
  • International Journal of Computer Vision
  • Year:
  • 1999

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Abstract

Segmentation of MR brain images using intensity values is severelylimited owing to field inhomogeneities, susceptibility artifacts andpartial volume effects. Edge based segmentation methods suffer fromspurious edges and gaps in boundaries. A multiscale method to MRI brainsegmentation is presented which uses both edge and intensity information. First a multiscale representation of an image is created, which can bemade edge dependent to favor intra-tissue diffusion over inter-tissuediffusion. Subsequently a multiscale linking model (the hyperstack) isused to group voxels into a number of objects based on intensity. It is shown that both an improvement in accuracy and a reduction inimage post-processing can be achieved if edge dependent diffusion isused instead of linear diffusion. The combination of edge dependentdiffusion and intensity based linking facilitates segmentation of greymatter, white matter and cerebrospinal fluid with minimal user interaction.To segment the total brain (white matter plus grey matter) morphologicaloperations are applied to remove small bridges between the brain and cranium.If the total brain is segmented, grey matter, white matter andcerebrospinal fluid can be segmented by joining a small number of segments.Using a supervised segmentation technique and MRI simulations of a brainphantom for validation it is shown that the errors are in the order ofor smaller than reported in literature.