Improving Objectivity and Scalability in Protein Crystallization: Integrating Image Analysis With Knowledge Discovery

Authors:
Igor Jurisica;Patrick Rogers;Janice I. Glasgow;Robert J. Collins;Jennifer R. Wolfley;Joseph R. Luft;Goerge T. DeTitta
Affiliations:
-;-;-;-;-;-;-
Venue:
IEEE Intelligent Systems
Year:
2001

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Abstract

This article describes issues related to integrating image analysis techniques with knowledge discovery and case-based reasoning. Although the work applies to many problem domains, here we focus on analyzing and classifying outcomes of protein crystallization experiments in high-throughput structural genomics. We apply the fast Fourier transform to analyze image content to extract important features of the spectrum. We use a combination of these features to classify crystallization experiments' outcomes. Although humans can analyze images more flexibly, a computational approach makes the process scalable and more objective. We evaluate the classification process and present results on how we can combine automatically extracted features to discover important crystallographic knowledge.