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Abstract: INTAP (Interoperability Technology Association for Information Processing, Japan), CBOP (Consortium for Business Object Promotion), MEDIS-DC (Medical Information System Development Center) and JAHIS (Japanese Association of Healthcare Information Systems Industry) have completed the initial phase of the Japanese Healthcare Domain Reference Enterprise Model project. The goal of the project is to define a reference healthcare domain model using ISO/IEC and ITU-T standardized RM-ODP framework. The initial phase focused on modeling the enterprise aspect of hospital information systems in Japan. RM-ODP Enterprise Viewpoint Language and UML were used as the key languages. This paper presents the results of the initial phase of the project, and discusses issues we faced during model development.