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In order to assist researchers with conducting their complex scientific experimentation and to support their collaboration with other scientists, modern advances in the IT area can be properly applied to the domain of experimental sciences. The main requirements identified in this domain include management of large data sets, distributed collaboration support, and high-performance issues, among others. The Virtual Laboratory project initiated at the University of Amsterdam aims at the development of a hardware and software reference architecture, and an open, flexible and configurable laboratory framework to enable scientists and engineers to work on their experimentation problems, while making optimum use of modern information technology approaches. This paper first describes the current design of a multi-layer architecture for this Scientific Virtual Laboratory, and then focuses further on the cooperative information management layer of this architecture, and exemplifying its application to experimentation domain of biology.