Computer
Representation of highly-complex knowledge in a database
Journal of Intelligent Information Systems - Special issue on next generation information technologies
A framework for knowledge-based temporal abstraction
Artificial Intelligence
Journal of Intelligent Information Systems - Special issue on integrating artificial intelligene and database technologies
The TSQL2 Temporal Query Language
The TSQL2 Temporal Query Language
Dynamic temporal interpretation contexts for temporal abstraction
Annals of Mathematics and Artificial Intelligence
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ICDE '96 Proceedings of the Twelfth International Conference on Data Engineering
TEMPORAL REASONING IN MEDICAL EXPERT SYSTEMS
TEMPORAL REASONING IN MEDICAL EXPERT SYSTEMS
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IJCAI'93 Proceedings of the 13th international joint conference on Artifical intelligence - Volume 1
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ECCBR '02 Proceedings of the 6th European Conference on Advances in Case-Based Reasoning
A Case-Based Approach for the Classification of Medical Time Series
ISMDA '01 Proceedings of the Second International Symposium on Medical Data Analysis
Interface of Inference Models with Concept and Medical Record Models
AIME '01 Proceedings of the 8th Conference on AI in Medicine in Europe: Artificial Intelligence Medicine
Prototypes for Medical Case-Based Applications
ICDM '08 Proceedings of the 8th industrial conference on Advances in Data Mining: Medical Applications, E-Commerce, Marketing, and Theoretical Aspects
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Advanced Web and NetworkTechnologies, and Applications
An ontological modeling approach to cerebrovascular disease studies: The NEUROWEB case
Journal of Biomedical Informatics
Time-oriented question answering from clinical narratives sing semantic-web techniques
ISWC'10 Proceedings of the 9th international semantic web conference on The semantic web - Volume Part II
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Proceedings of the first international workshop on Managing interoperability and complexity in health systems
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Both clinical management of patients and clinical research are essentially time-oriented endeavors. In this paper, I emphasize the crucial role of temporal-reasoning and temporal-maintenance tasks for modern medical information and decision support systems. Both tasks are important for management of clinical data, but the first is often approached mainly through artificial-intelligence methodologies, while the other is usually investigated by the database community. However, both tasks require careful consideration of common theoretical issues, such as the structure of time. In addition, common to both of these research areas are tasks such as temporal abstraction and management of variable temporal granularity. Finally, both tasks are highly relevant for applications such as patient monitoring, support to application of therapy guidelines, assessment of the quality of guideline application, and visualization and exploration of time-oriented biomedical data. I propose that integration of the two areas should be a major research and development goal. I demonstrate one integration approach by presenting a new architecture, a temporal mediator, which combines temporal reasoning and temporal maintenance, and integrates the management of clinical databases and medical knowledge bases. I present and discuss examples of using the temporal mediator for several of the application areas mentioned. I conclude by reemphasizing the importance of effective knowledge representation, knowledge reuse, and knowledge sharing methods to medical decision support systems in general, and to time-oriented systems in particular.