A Simulated Annealing and Resampling Method for Training Perceptrons to Classify Gene-Expression Data

  • Authors:
  • Andreas Alexander Albrecht;Staal A. Vinterbo;C. K. Wong;Lucila Ohno-Machado

  • Affiliations:
  • -;-;-;-

  • Venue:
  • ICANN '02 Proceedings of the International Conference on Artificial Neural Networks
  • Year:
  • 2002

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Abstract

We investigate the use of perceptrons for classification of microarray data. Small round blue cell tumours of childhood are difficult to classify both clinically and via routine histology. Khan et al. [10] showed that a system of artificial neural networks can utilize gene expression measurements from microarrays and classify these tumours into four different categories. We used a simulated annealing-based method in learning a system of perceptrons, each obtained by resampling of the training set. Our results are comparable to those of Khan et al., indicating that there is a role for perceptrons in the classification of tumours based on gene expression data. We also show that it is critical to perform feature selection in this type of models.