Tandem Cyclic Alignment

  • Authors:
  • Gary Benson

  • Affiliations:
  • -

  • Venue:
  • CPM '01 Proceedings of the 12th Annual Symposium on Combinatorial Pattern Matching
  • Year:
  • 2001

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Abstract

We present a solution for the following problem. Given two sequences X = x1x2 ... xn and Y = y1y2 ...ym, n 驴 m, find the best scoring alignment of X驴 = Xk[i] vs Y over all possible pairs (k, i), for k = 1, 2, ... and 1 驴 i 驴 n, where X[i] is the cyclic permutation of X, Xk[i] is the concatenation of k complete copies of X[i] (k tandem copies), and the alignment must include all of Y and all of X驴. Our algorithm allows any alignment scoring scheme with additive gap costs and runs in time O(nm log n). We have used it to identify related tandem repeats in the C. elegans genome as part of the development of a multigenome database of tandem repeats.