Application of Multiobjective Evolutionary Algorithms for Dose Optimization Problems in Brachytherapy

  • Authors:
  • Michael Lahanas;Natasa Milickovic;Dimos Baltas;Nikolaos Zamboglou

  • Affiliations:
  • -;-;-;-

  • Venue:
  • EMO '01 Proceedings of the First International Conference on Evolutionary Multi-Criterion Optimization
  • Year:
  • 2001

Quantified Score

Hi-index 0.00

Visualization

Abstract

In High Dose Rate (HDR) brachytherapy the conventional dose optimization algorithms consider the multiple objectives in form of an aggregate function which combines individual objectives into a single utility value. As a result, the optimization problem becomes single objective, prior to optimization. Up to 300 parameters must be optimized satisfying objectives which are often competing. We use multiobjective dose optimization methods where the objectives are expressed in terms of quantities derived from dose-volume histograms or in terms of statistical parameters of dose distributions from a small number of sampling points. For the last approach we compare the optimization results of evolutionary multiobjective algorithms with deterministic optimization methods. The deterministic algorithms are very efficient and produce the best results. The performance of the multiobjective evolutionary algorithms is improved if a small part of the population is initialized by deterministic algorithms.