Handbook of Evolutionary Computation
Handbook of Evolutionary Computation
Multiobjective Evolutionary Algorithms: Analyzing the State-of-the-Art
Evolutionary Computation
Comparison of Multiobjective Evolutionary Algorithms: Empirical Results
Evolutionary Computation
An overview of evolutionary algorithms in multiobjective optimization
Evolutionary Computation
ADMA '08 Proceedings of the 4th international conference on Advanced Data Mining and Applications
Modeling and optimization of combined cytostatic and cytotoxic cancer chemotherapy
Artificial Intelligence in Medicine
Multi-objective optimization of cancer chemotherapy treatment
EUROCAST'11 Proceedings of the 13th international conference on Computer Aided Systems Theory - Volume Part II
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The main objectives of cancer treatment in general, and of cancer chemotherapy in particular, are to eradicate the tumour and to prolong the patient survival time. Traditionally, treatments are optimised with only one objective in mind. As a result of this, a particular patient may be treated in the wrong way if the decision about the most appropriate treatment objective was inadequate. To partially alleviate this problem, we show in this paper how the multi-objective approach to chemotherapy optimisation can be used. This approach provides the oncologist with versatile treatment strategies that can be applied in ambiguous cases. However, the conflicting nature of treatment objectives and the non-linearity of some of the constraints imposed on treatment schedules make it difficult to utilise traditional methods of multi-objective optimisation. Evolutionary Algorithms (EA), on the other hand, are often seen as the most suitable method for tackling the problems exhibiting such characteristics. Our present study proves this to be true and shows that EA are capable of finding solutions undetectable by other optimisation techniques.