Multifacetted modelling and discrete event simulation
Multifacetted modelling and discrete event simulation
The STATEMATE semantics of statecharts
ACM Transactions on Software Engineering and Methodology (TOSEM)
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Future Generation Computer Systems
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ACM Transactions on Modeling and Computer Simulation (TOMACS)
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Simulation modeling methodology: principles and etiology of decision support
Simulation modeling methodology: principles and etiology of decision support
iSimBioSys: A Discrete Event Simulation Platform for 'in silico' study of biological systems
ANSS '06 Proceedings of the 39th annual Symposium on Simulation
Towards reusing model components in systems biology
CMSB'04 Proceedings of the 20 international conference on Computational Methods in Systems Biology
Discrete event multi-level models for systems biology
Transactions on Computational Systems Biology I
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Typically differential equations are employed to simulate metabolic processes. To develop a valid continuous model based on differential equations requires accurate parameter estimations; an accuracy which is often difficult to achieve, due to the lacko f data. In addition processes in metabolic pathways, e.g. metabolite channeling, seem to be of a rather qualitative and discrete nature. With respect to the available data and to the perception of the underlying system a discrete rather than a continuous approach to modeling and simulation seems more adequate. However, a discrete approach does not necessarily imply a more abstract view on the system. If we move from macro to micro and multi-level modeling, aspects of subsystems and their interactions, which have been only implicitly represented, are now explicit part of the model. Based on the simulation environment James we started exploring phenomena of metabolite channeling on different levels of abstractions. James is a discrete event simulation system and supports a modular hierarchical composition of models, the change of modeling structure during simulation, and a distributed, parallel execution of models.