Identification of genetic networks by strategic gene disruptions and gene overexpressions under a boolean model

  • Authors:
  • Tatsuya Akutsu;Satoru Kuhara;Osamu Maruyama;Satoru Miyano

  • Affiliations:
  • Human Genome Center, Institute of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan;Graduate School of Genetic Resources Technology, Kyushu University, Hakozaki 6-10-1, Higashi-ku, Fukuoka 812-8581, Japan;Graduate School of Mathematics, Kyushu University, Hakozaki 6-10-1, Higashi-ku, Fukuoka 812-8581, Japan;Human Genome Center, Institute of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan

  • Venue:
  • Theoretical Computer Science - Selected papers in honour of Setsuo Arikawa
  • Year:
  • 2003

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Abstract

Analysis of the interactions between genes by systematic gene disruptions and gene overexpressions is an important topic in molecular biology. This paper analyses the problem of identifying a genetic network from the data obtained by multiple gene disruptions and overexpressions in regard to the number of experiments and the complexity of experiments. An experiment consists of simultaneous gene disruptions and overexpressions and the complexity of an experiment is the number of genes disrupted or overexpressed. We define a genetic network as a boolean network and show a series of algorithms which describe methods for identifying the underlying genetic network by such experiments. Some lower bounds on the number of experiments required for the identification are also proved for some cases.