Time Series Analysis of Gene Expression and Location Data

Authors:
Chen-Hsiang Yeang;Tommi Jaakkola
Affiliations:
-;-
Venue:
BIBE '03 Proceedings of the 3rd IEEE Symposium on BioInformatics and BioEngineering
Year:
2003

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Abstract

We develop a method for integrating time series expression profiles and factor-gene binding data to quantify dynamic aspects of gene regulation. We estimate latencies fo transcription activation by explaining time correlations between gene expression profiles through available factor-gene binding information. The resulting aligned expression profiles are subsequently clustered and again combined with binding information to determine groups or subgroups of co-regulated genes. The predictions derived from this approach are consistent with existing results ([11], [8]). Our analysis also provides several hypotheses not implicated in previous studies.