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This paper elaborates on mechanisms by which users, data, and applications can be decoupled from individualcomputers and administrative domains. The mechanisms, which consist of logical user accounts and a virtual file system, introduce a layer of abstraction between the physical computing infrastructure and the virtual computational grid perceived by users. This abstraction converts compute servers into interchangeable parts, allowing a computational grid to assemble computing systems at run time without being limited by the traditional constraints associated with user accounts, file systems, and administrative domains. The described approach has already been deployed in the context of PUNCH (the Purdue University Network Computing Hubs), and is unique in its ability to integrate unmodified applications (even commercial ones) and existing computing infrastructure into a heterogeneous, wide-area network computing environment.