Two operative concepts for the post-genomic era: the "mémoire vive" of the cell and a molecular algebra

Authors:
Simone Bentolila
Affiliations:
-
Venue:
CSB '03 Proceedings of the IEEE Computer Society Conference on Bioinformatics
Year:
2003

Citing 2
Cited 0

GenExpress: A Computer System for Description, Analysis and Recognition of Regulatory Sequences in Eukaryotic Genome

ISMB '98 Proceedings of the 6th International Conference on Intelligent Systems for Molecular Biology
First draft of a report on the EDVAC

First draft of a report on the EDVAC

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Abstract

The first successes in cloning experiments and stemcell "reprogramming" have already demonstrated theprimordial role of cellular working-space memory andregulatory mechanisms, which use the knowledge storedin the DNA database in read mode. We present ananalogy between living systems and informatics systemsby considering: 1) the cell cytoplasm as a memory deviceaccessible as read/write; 2) the mechanisms of regulationas a programming language defined by a grammar, amolecular algebra; 3) biological processes as volatileprograms which are executed without being written; 4)DNA as a database in read only mode. We also presentapplications to two biological algorithms: the immuneresponse and glycogen metabolism.