A Statistical Model of Proteolytic Digestion

Authors:
I-Jeng Wang;Christopher P. Diehl;Fernando J. Pineda
Affiliations:
-;-;-
Venue:
CSB '03 Proceedings of the IEEE Computer Society Conference on Bioinformatics
Year:
2003

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Abstract

We present a stochastic model of proteolytic digestion ofa proteome, assuming the distribution of parent proteinlengths in the proteome, the relative abundances of the 20amino acids in the proteome, and the digestion "rules" ofthe enzyme used in the digestion. We derived a closedform expression for the fragment mass distribution for alarge class of enzymes including the widely used Trypsin.The expression uses the distribution of lengths in amixture of proteins taken from a proteome, as well as therelative abundances of the 20 amino acids in theproteome. The agreement between theory and the in silicodigest is excellent.