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This paper presents a design framework for wearableelectronic textiles. The focus is on the design andsimulation issues that arise from the interaction of theelectronic textile, the human body, and the environment.To assist in design choices within this framework, asimulation environment is described that uses Ptolemy IIto integrate models of the physical environment, humanlocomotion, sensor behavior, network communication,power consumption, and software execution. We describeresults for two e-textile design case studies, a shape-sensinggarment and a wearable phased array ofmicrophones, demonstrating how the design frameworkencompasses the effects of design variables for wearableelectronic textiles.