Adaptive Modeling of Biochemical Pathways

Authors:
R. Brause
Affiliations:
-
Venue:
ICTAI '03 Proceedings of the 15th IEEE International Conference on Tools with Artificial Intelligence
Year:
2003

Citing 0
Cited 3

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Abstract

In bioinformatics, biochemical pathways can be modeled by many differential equations. It is still an open problem how to fit the huge amount of parameters of the equations to the available data. Here, the approach of systematically learning the parameters is necessary.In this paper, for the small, important example of inflammation modeling a network is constructed and different learning algorithms are proposed. It turned out that due to the nonlinear dynamics evolutionary approaches are necessary to fit the parameters for sparse, given data.