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Over the past couple of years, the Internet has taken off and organizations will soon reap economic benefits on it. E-commerce will therefore hopefully emerge as an efficient yet effective mode of creating new markets although most managers still doubt the economic impact and profitability it has. Enabled by global telecommunication networks and the convergence of computing, telecom, entertainment and publishing industries, e-commerce is supplanting (may be replacing) traditional commerce. In the process, it is creating new economic opportunities for today's businesses, creating new market structures. Managers of tomorrow must therefore understand what e-commerce is; how the approach to this concept will be; and how it will affect the economic position of the organization.These questions are asked: What is the return on investment (ROI) on e-commerce? What is the effect of e-commerce on the strategic alignment of the organization? In addition, what is the economic effect of the strategic alignment on the organization? This paper explains the economic impact of e-commerce and how it can be used to create new markets and to improve the strategic alignment of the organization.