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This paper describes our empirical research effort to design, implement and deploy a middleware platform that addresses several key issues in pervasive computing. We designed an architecture, called the Bio-Networking Architecture, which models a pervasive network application as a collection of autonomic agents designed after several biological concepts and mechanisms. The biologically-inspired agents inherently address the key issues in pervasive computing, and our middleware platform aids developing and executing the agents on networks. We identify a set of requirements to the middleware platform through analyzing the features of our agents, and describe the design and implementation of the platform, showing how the platform satisfies the identified requirements. We also present some measurement results to illustrate scalability and efficiency of the platform.