Interface surfaces for protein-protein complexes

Authors:
Yih-En Andrew Ban;Herbert Edelsbrunner;Johannes Rudolph
Affiliations:
Duke University, Durham, NC;Duke University, Durham, NC;Duke University, Durham, NC
Venue:
RECOMB '04 Proceedings of the eighth annual international conference on Resaerch in computational molecular biology
Year:
2004

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Abstract

Protein-protein interactions, which form the basis for most cellular processes, result in the formation of protein interfaces. Believing that the local shape of proteins is crucial, we take a geometric approach and present a definition of an interface surface formed by two or more proteins. We also present an algorithm and study the geometric and topological properties of these surfaces, thus paving the way for future biochemical studies of protein-protein interactions.