Development of Two-Stage SVM-RFE Gene Selection Strategy for Microarray Expression Data Analysis
IEEE/ACM Transactions on Computational Biology and Bioinformatics (TCBB)
A semi-supervised approach to projected clustering with applications to microarray data
International Journal of Data Mining and Bioinformatics
SNP specific extraction and analysis using shrunken dissimilarity measure
Proceedings of the First ACM International Conference on Bioinformatics and Computational Biology
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The morbidity rate of cancer victims varies greatly for similar patients who receive similar treatments. It is hypothesized that this variation can be explained by the genetic heterogeneity of the disease. DNA Microarrays, which can simultaneously measure the expression level of thousands of different genes, have been successfully used to identify such genetic differences. However, microarray data typically has a large number of features and relatively few observations, meaning that conventional machine learning tools can fail when applied to such data. We describe a novel procedure called "nearest shrunken centroids" that has successfully detected clinically relevant genetic differences in cancer patients. This procedure has the potential to become a powerful tool for diagnosing and treating cancer.