Efficient Methods for Generating Optimal Single and Multiple Spaced Seeds

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  • Affiliations:
  • Venue:
  • BIBE '04 Proceedings of the 4th IEEE Symposium on Bioinformatics and Bioengineering
  • Year:
  • 2004

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Abstract

Biologists highly rely on good algorithms for findinghomologous regions in bimolecular sequences. An advancedhomology search program named PatternHunterhas recently been developed. Unlike the well-known programBLAST using a consecutive model, it utilizes a spacedseed model to attain higher sensitivity. We have developeda new program, which extends PatternHunter from a singlespaced model to a multiple spaced model. In this paper,we describe methods for finding optimal single and multiplespaced models.