Computational Methods for Predicting Intramolecular G-Quadruplexes in Nucleotide Sequences

Authors:
Lawrence D'Antonio;Paramjeet Bagga
Affiliations:
Ramapo College of New Jersey;Ramapo College of New Jersey
Venue:
CSB '04 Proceedings of the 2004 IEEE Computational Systems Bioinformatics Conference
Year:
2004

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Theoretical Computer Science

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Abstract

Guanine-rich sequences, including those that form G-quadruplexes, are abundant in regions of biological significance. In order to map putative G-quadruplex elements within mammalian genes we have created a suite of computational tools. This suite contains algorithms to search genes for occurrences of the G-quadruplex motif and determine their distribution near RNA processing sites.