Probabilistic Principal Surfaces for Yeast Gene Microarray Data Mining

  • Authors:
  • Antonino Staiano;Lara De Vinco;Angelo Ciaramella;Giancarlo Raiconi;Roberto Tagliaferri;Roberto Amato;Giuseppe Longo;Ciro Donalek;Gennaro Miele;Diego Di Bernardo

  • Affiliations:
  • Università di Salerno, Italy;Università di Salerno, Italy;Università di Salerno, Italy;Università di Salerno, Italy;Università di Salerno, Italy;Università Federico II di Napoli and INFN Napoli Unit, Italy;Università Federico II di Napoli and INFN Napoli Unit, Italy;Università Federico II di Napoli and INFN Napoli Unit, Italy;Università Federico II di Napoli and INFN Napoli Unit, Italy;Telethon Institute for Genetics and Medicine, Italy

  • Venue:
  • ICDM '04 Proceedings of the Fourth IEEE International Conference on Data Mining
  • Year:
  • 2004

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Abstract

The recent technological advances are producing huge data sets in almost all fields of scientific research, from astronomy to genetics. Although each research field often requires ad-hoc, fine tuned, procedures to properly exploit all the available information inherently present in the data, there is an urgent need for a new generation of general computational theories and tools capable to boost most human activities of data analysis. Here we propose Probabilistic Principal Surfaces (PPS) as an effective high-D data visualization and clustering tool for data mining applications, emphasizing its flexibility and generality of use in data-rich field. In order to better illustrate the potentialities of the method, we also provide a real world case-study by discussing the use of PPS for the analysis of yeast gene expression levels from microarray chips.