Approximation of dynamical systems using s-systems theory: application to biological systems

  • Authors:
  • Laurent Tournier

  • Affiliations:
  • Laboratoire de Modélisation et Calcul, Grenoble cedex, France

  • Venue:
  • Proceedings of the 2005 international symposium on Symbolic and algebraic computation
  • Year:
  • 2005

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Abstract

In this article we propose a new symbolic-numeric algorithm to find positive equilibria of a n-dimensional dynamical system. This algorithm uses a symbolic manipulation of ODE in order to give a local approximation of differential equations with power-law dynamics (S-systems). A numerical calculus is then performed to converge towards an equilibrium, giving at the same time a S-system approximating the initial system around this equilibrium. This algorithm has been applied to a real biological example in 14 dimensions which is a subsystem of a metabolic pathway in Arabidopsis Thaliana.