XS-systems: eXtended S-Systems and Algebraic Differential Automata for Modeling Cellular Behavior
HiPC '02 Proceedings of the 9th International Conference on High Performance Computing
XS-systems: eXtended S-Systems and Algebraic Differential Automata for Modeling Cellular Behavior
HiPC '02 Proceedings of the 9th International Conference on High Performance Computing
A computer algebra approach to biological systems
ISSAC '03 Proceedings of the 2003 international symposium on Symbolic and algebraic computation
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In this article we propose a new symbolic-numeric algorithm to find positive equilibria of a n-dimensional dynamical system. This algorithm uses a symbolic manipulation of ODE in order to give a local approximation of differential equations with power-law dynamics (S-systems). A numerical calculus is then performed to converge towards an equilibrium, giving at the same time a S-system approximating the initial system around this equilibrium. This algorithm has been applied to a real biological example in 14 dimensions which is a subsystem of a metabolic pathway in Arabidopsis Thaliana.