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Microreactors lend themselves to a relatively simple implementation of DNA computing. Not only is the design of the DNA library critical for the success of the system but also the architecture of the microfluidic structure. Microreactors can be configured as Boolean operators. This paper will show that biomolecular computing can be performed with elementary building blocks, analogous to electronic logic gates. These logical operations will be performed using negative selection. Furthermore, an alternative bead barrier is introduced which can render the computer re-programmable and shows an principle architecture for selection and analysis.