On the complexity of finding emerging patterns

  • Authors:
  • Lusheng Wang;Hao Zhao;Guozhu Dong;Jianping Li

  • Affiliations:
  • Department of Computer Science, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon, Hong Kong, China;Department of Computer Science, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon, Hong Kong, China;Dept. of CSE, Wright State University, 3640 Colonel Glenn Hwy., Dayton, OH;Department of Computer Science, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon, Hong Kong, China

  • Venue:
  • Theoretical Computer Science - Pattern discovery in the post genome
  • Year:
  • 2005

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Abstract

Emerging patterns have been studied as a useful type of pattern for the diagnosis and understanding of diseases based on the analysis of gene expression profiles. They are useful for capturing interactions among genes (or other biological entities), for capturing signature patterns for disease subtypes, and deriving potential disease treatment plans, etc. In this paper we study the complexity of finding emerging patterns (with the highest frequency). We first show that the problem is MAX SNP-hard. This implies that polynomial time approximation schemes do not exist for the problem unless P = NP. We then prove that for any constant δ logδn in polynomial time unless NP ⊆ DTIME[2polylog n], where n is the number of positions in a pattern.