Modelling, property verification and behavioural equivalence of lactose operon regulation
Computers in Biology and Medicine
Double iterative optimisation for metabolic network-based drug target identification
International Journal of Data Mining and Bioinformatics
Computers in Biology and Medicine
Modeling and property verification of lactose operon regulation
BSB'05 Proceedings of the 2005 Brazilian conference on Advances in Bioinformatics and Computational Biology
Graph-based term weighting for information retrieval
Information Retrieval
Hi-index | 3.84 |
Understanding the architecture of physiological functions from annotated genome sequences is a major task for postgenomic biology. From the annotated genome sequence of the microbe Escherichia coli, we propose a general quantitative definition of enzyme importance in a metabolic network. Using a graph analysis of its metabolism, we relate the extent of the topological damage generated in the metabolic network by the deletion of an enzyme to the experimentally determined viability of the organism in the absence of that enzyme. We show that the network is robust and that the extent of the damage relates to enzyme importance. We predict that a large fraction (91%) of enzymes causes little damage when removed, while a small group (9%) can cause serious damage. Experimental results confirm that this group contains the majority of essential enzymes. The results may reveal a universal property of metabolic networks.