GENIUS II: a high-throughput database system for linking ORFs in complete genomes to known protein three-dimensional structures

  • Authors:

  • Yukimitsu Yabuki;Yuri Mukai;Mark B. Swindells;Makiko Suwa

  • Affiliations:

  • Computational Biology Research Center (CBRC), National Institute of Advanced Industrial Science and Technology (AIST), Aomi Frontier Building 17F, 2-43 Aomi, Koto-ku, Tokyo 135-0064, Japan,;Computational Biology Research Center (CBRC), National Institute of Advanced Industrial Science and Technology (AIST), Aomi Frontier Building 17F, 2-43 Aomi, Koto-ku, Tokyo 135-0064, Japan,;Inpharmatica Ltd., 60 Charlotte Street, London, W1P2AX, UK;Computational Biology Research Center (CBRC), National Institute of Advanced Industrial Science and Technology (AIST), Aomi Frontier Building 17F, 2-43 Aomi, Koto-ku, Tokyo 135-0064, Japan,

  • Venue:
  • Bioinformatics
  • Year:
  • 2004

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Abstract

Summary: GENIUS II is an automated database system in which open reading frames (ORFs) in complete genomes are assigned to known protein three-dimensional (3D) structures. The system uses the multiple intermediate sequence search method in which query and target sequences are linked by intermediate sequences gathered by PSI-BLAST search. By applying the system to 129 complete genomes, 43.8% on average of the ORFs in the genomes were assigned to known 3D structures and the results are available for free at GENIUS II web site. Availability: http://genius.cbrc.jp Supplementary information: http://genius.cbrc.jp/summary_linking.html