Ontologizing gene-expression microarray data: characterizing clusters with Gene Ontology

Authors:
Peter N. Robinson;Andreas Wollstein;Ulrike Böhme;Brad Beattie
Affiliations:
Institute of Medical Genetics, Charité University Hospital, Humboldt University, Augustenburger Platz 1, 13353 Berlin, Germany;Institute of Medical Genetics, Charité University Hospital, Humboldt University, Augustenburger Platz 1, 13353 Berlin, Germany;Institute of Medical Genetics, Charité University Hospital, Humboldt University, Augustenburger Platz 1, 13353 Berlin, Germany;Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, NY, USA
Venue:
Bioinformatics
Year:
2004

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Abstract

Summary: An XML-based Java application is described that provides a function-oriented overview of the results of cluster analysis of gene-expression microarray data based on Gene Ontology terms and associations. The application generates one HTML page with listings of the frequencies of explicit and implicit Gene Ontology annotations for each cluster, and separate, linked pages with listings of explicit annotations for each gene in a cluster. Availability: http://www.charite.de/ch/medgen/ontologizer