IEEE/ACM Transactions on Computational Biology and Bioinformatics (TCBB)
Cascaded Bidirectional Recurrent Neural Networks for Protein Secondary Structure Prediction
IEEE/ACM Transactions on Computational Biology and Bioinformatics (TCBB)
Protein secondary structure prediction using distance based classifiers
International Journal of Approximate Reasoning
Analysis of covariations of sequence physicochemical properties
MCBC'07 Proceedings of the 8th Conference on 8th WSEAS Int. Conference on Mathematics and Computers in Biology and Chemistry - Volume 8
Classification tree based protein structure distances for testing sequence-structure correlation
Computers in Biology and Medicine
Detecting Statistical Covariations of Sequence Physicochemical Properties
BSB '08 Proceedings of the 3rd Brazilian symposium on Bioinformatics: Advances in Bioinformatics and Computational Biology
Computational Biology and Chemistry
Conditional graphical models for protein structure prediction
Conditional graphical models for protein structure prediction
Exploiting Intrastructure Information for Secondary Structure Prediction with Multifaceted Pipelines
IEEE/ACM Transactions on Computational Biology and Bioinformatics (TCBB)
Applied Computational Intelligence and Soft Computing
Applied Computational Intelligence and Soft Computing
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Motivation: Is protein secondary structure primarily determined by local interactions between residues closely spaced along the amino acid backbone or by non-local tertiary interactions? To answer this question, we measure the entropy densities of primary and secondary structure sequences, and the local inter-sequence mutual information density. Results: We find that the important inter-sequence interactions are short ranged, that correlations between neighboring amino acids are essentially uninformative and that only one-fourth of the total information needed to determine the secondary structure is available from local inter-sequence correlations. These observations support the view that the majority of most proteins fold via a cooperative process where secondary and tertiary structure form concurrently. Moreover, existing single-sequence secondary structure prediction algorithms are almost optimal, and we should not expect a dramatic improvement in prediction accuracy. Availability: Both the data sets and analysis code are freely available from our Web site at http://compbio.berkeley.edu/