A Bayesian derived network of breast pathology co-occurrence
Journal of Biomedical Informatics
Two-phase prediction of protein functions from biological literature based on Gini-Index
Proceedings of the 5th International Conference on Ubiquitous Information Management and Communication
Towards an automated analysis of biomedical abstracts
DILS'06 Proceedings of the Third international conference on Data Integration in the Life Sciences
Chapter 15: search computing and the life sciences
Search Computing
International Journal of Data Mining and Bioinformatics
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Motivation: The advent of high-throughput experiments in molecular biology creates a need for methods to efficiently extract and use information for large numbers of genes. Recently, the associative concept space (ACS) has been developed for the representation of information extracted from biomedical literature. The ACS is a Euclidean space in which thesaurus concepts are positioned and the distances between concepts indicates their relatedness. The ACS uses co-occurrence of concepts as a source of information. In this paper we evaluate how well the system can retrieve functionally related genes and we compare its performance with a simple gene co-occurrence method. Results: To assess the performance of the ACS we composed a test set of five groups of functionally related genes. With the ACS good scores were obtained for four of the five groups. When compared to the gene co-occurrence method, the ACS is capable of revealing more functional biological relations and can achieve results with less literature available per gene. Hierarchical clustering was performed on the ACS output, as a potential aid to users, and was found to provide useful clusters. Our results suggest that the algorithm can be of value for researchers studying large numbers of genes. Availability: The ACS program is available upon request from the authors. Contact: r.jelier@erasmusmc.nl