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The Analysis Of Large Data Sets (AIDS) project was initiated at the Pacific Northwest Laboratories in 1978 through funding from DOE/BES Applied Mathematical Sciences. At that time, it was evident that the technical cornnunity's ability to collect scientific data was far outstripping existing capabilites to manipulate, display, and analyze such large data sets. Therefore, a new research direction in the analysis of large data sets was established. The AIDS project is composed of a team of statisticians and computer scientists. Their close interaction has been a key factor in contributing to our discoveries and future directions for analyzing large data sets. To help guide this program, an interdisciplinary team of consultants and reviewers were gathered together on an periodic basis to review progress and suggest research directions.This paper will discuss the motivation and initial goals of the AIDS project, the impact of large data sets, the data management issues addressed by ALDS, current research tasks and their impact on statistical data base management, and perspectives.