On carcinomas and other pathological entities: Research Articles

Authors:
Barry Smith;Anand Kumar;Werner Ceusters;Cornelius Rosse
Affiliations:
Ifomis, Univ. of Saarbrücken, Germany and Dept. of Philos., Univ. at Buffalo and Natl. Ctr. for Biomed. Ontol., USA and European Ctr. for Ontol. Res., Univ. of Saarbrücken, Germany;Ifomis, University of Saarbrücken, Germany;European Centre for Ontological Research, University of Saarbrücken, Germany;Department of Biological Structure, School of Medicine, University of Washington, Seattle, WA, USA
Venue:
Comparative and Functional Genomics
Year:
2005

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Abstract

Tumours, abscesses, cysts, scars and fractures are familiar types of what we shall call pathological continuant entities. The instances of such types exist always in or on anatomical structures, which thereby become transformed into pathological anatomical structures of corresponding types: a fractured tibia, a blistered thumb, a carcinomatous colon. In previous work on biomedical ontologies we showed how the provision of formal definitions for relations such as is_ a, part_ of and transformation_ of can facilitate the integration of such ontologies in ways which have the potential to support new kinds of automated reasoning. We here extend this approach to the treatment of pathologies, focusing especially on those pathological continuant entities which arise when organs become affected by carcinomas. Copyright © 2006 John Wiley & Sons, Ltd.