Gain Control by Concerted Changes in IA and IH Conductances

Authors:
Denis Burdakov
Affiliations:
Neurosciences Division, Biological Sciences, University of Manchester, Manchester, M13 9PT, U.K.
Venue:
Neural Computation
Year:
2005

Citing 0
Cited 3

Synergies Between Intrinsic and Synaptic Plasticity Mechanisms

Neural Computation
A sparse generative model of v1 simple cells with intrinsic plasticity

Neural Computation
Tuning low-voltage-activated a-current for silent gain modulation

Neural Computation

Quantified Score

Hi-index	0.00

Visualization

Abstract

Stability of intrinsic electrical activity and modulation of input-output gain are both important for neuronal information processing. It is therefore of interest to define biologically plausible parameters that allow these two features to coexist. Recent experiments indicate that in some biological neurons, the stability of spontaneous firing can arise from coregulated expression of the electrophysiologically opposing IA and IH currents. Here, I show that such balanced changes in IA and IH dramatically alter the slope of the relationship between the firing rate and driving current in a Hodgkin-Huxley-type model neuron. Concerted changes in IA and IH can thus control neuronal gain while preserving intrinsic activity.