An Accurate Measure of the Instantaneous Discharge Probability, with Application to Unitary Joint-Event Analysis

Authors:
Quentin Pauluis;Stuart N. Baker
Affiliations:
Laboratory of Neurophysiology, School of Medicine, Universite ´ Catholique de Louvain Brussels, Belgium;Department of Anatomy, University of Cambridge, Cambridge, CB2 3DY, U.K.
Venue:
Neural Computation
Year:
2000

Citing 3
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Abstract

We present an estimate for the instantaneous discharge probability of a neurone, based on single-trial spike-train analysis. By detecting points where the neurone abruptly changes its firing rate and treating them specially, the method is able to achieve smooth estimates yet avoid the blurring of significant changes. This estimate of instantaneous discharge probability is then applied to the method of unitary event analysis. We show that the unitary event analysis as originally conceived is highly sensitive to firing-rate nonstationarities and covariations, but that it can be considerably improved if calculations of statistical significance use an instantaneous discharge probability instead of a firing-rate estimate based on averaging across multiple trials.