Local optimization of neuron arbors
Biological Cybernetics
Analytical minimization of half-perimeter wirelength
ASP-DAC '00 Proceedings of the 2000 Asia and South Pacific Design Automation Conference
Exact Solution for the Optimal Neuronal Layout Problem
Neural Computation
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Given that brains and computers are similar in many respects, can vast experience in computer engineering help us understand brain design? Here we apply tools developed for physical design of computer chips to understand the layout of the nervous system. Starting with the known wiring diagram of the C. elegans nervous system, we predict the locations of synapses and extent of neurons that minimize the total wiring length. Comparing predicted locations of C. elegans neuronal cell bodies with the actual locations, we find reasonable agreement. Therefore, minimization of wiring length is an important consideration both in chip design and brain architecture. Furthermore, wire length minimization can be used to infer functional roles of neuronal components.