Regulation probability method for gene selection

Authors:
Hong-Qiang Wang;De-Shuang Huang
Affiliations:
Intelligent Computation Lab, Hefei Institute of Intelligent Machines, Chinese Academy of Science, P.O. Box 1130, Hefei, Anhui 230031, PR China and Department of Automation, University of Science a ...;Intelligent Computation Lab, Hefei Institute of Intelligent Machines, Chinese Academy of Science, P.O. Box 1130, Hefei, Anhui 230031, PR China
Venue:
Pattern Recognition Letters
Year:
2006

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Abstract

This paper proposes a novel method for gene selection. In the method, the gene regulation, an important mechanism of gene activities, is first introduced, and then the probabilities of gene regulation are estimated. These probabilities can be seen as the gene regulation information and can be used for gene selection. The applications to the leukemia dataset and the colon dataset suggest that our proposed method is effective, efficient, and competitive to the previous methods.