Prediction of vascular tissue engineering results with artificial neural networks

Authors:
Jie Xu;Haiyan Ge;Xiaolin Zhou;Jinglong Yan;Qiang Chi;Zhipeng Zhang
Affiliations:
Dao Wai District, Harbin, Hei Long Jiang, PR China and Department of General Surgery, The Shanghai Tenth People's Hospital of Tongji University, Shanghai, PR China;Department of General Surgery, The Shanghai Tenth People's Hospital of Tongji University, Shanghai, PR China;Department of Neurology, The Shanghai First People's Hospital of Shanghai Jiao Tong University, Shanghai, PR China;Department of Orthopaedics, The First Hospital of Harbin Medical University, Heilongjiang, PR China;Department of General Surgery, The Second Hospital of Harbin Medical University, Heilongjiang, PR China;Department of Orthopaedics, The First Hospital of Harbin Medical University, Heilongjiang, PR China
Venue:
Journal of Biomedical Informatics
Year:
2005

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Abstract

Tissue engineers are often confused on finding the most successful strategy for specific patient. In this study, we used artificial neural networks to predict the outcomes of different vascular tissue engineering strategies, thus providing advisory information for experimental designers. Over 30 variables were used as features of the tissue engineering strategies. Different architectures of artificial neural networks with back propagation algorithm were tested to obtain the best model configuration for the prediction of the tissue engineering strategies. In the computational experiments, the artificial neural networks with one and two hidden layers could, respectively, detect unsuccessful strategies with the highest predictive accuracy of 91.45 and 94.24%. In conclusion, artificial intelligence has great potential in tissue engineering decision support. It can provide accurate advisory information for tissue engineers, thus reducing failures and improving therapeutic effects.