Two-phase clustering strategy for gene expression data sets

Authors:
Dirk Habich;Thomas Wächter;Wolfgang Lehner;Christian Pilarsky
Affiliations:
Dresden University of Technology, Germany;Dresden University of Technology, Germany;Dresden University of Technology, Germany;Dresden University of Technology
Venue:
Proceedings of the 2006 ACM symposium on Applied computing
Year:
2006

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Abstract

In the context of genome research, the method of gene expression analysis has been used for several years. Related microarray experiments are conducted all over the world, and consequently, a vast amount of microarray data sets are produced. Having access to this variety of repositories, researchers would like to incorporate this data in their analyses to increase the statistical significance of their results. In this paper, we present a new two-phase clustering strategy which is based on the combination of local clustering results to obtain a global clustering. The advantage of such a technique is that each microarray data set can be normalized and clustered separately. The set of different relevant local clustering results is then used to calculate the global clustering result. Furthermore, we present an approach based on technical as well as biological quality measures to determine weighting factors for quantifying the local results proportion within the global result. The better the attested quality of the local results, the stronger their impact on the global result.